Persistent Sexual Side Effects of Finasteride for Male Pattern Hair Loss

Persistent Sexual Side Effects of Finasteride for Male Pattern Hair Loss


Keywords:Erectile Dysfunction;Finasteride;Libido;5 Alpha Reductase Inhibitor;Propecia;Sexual Side Effects


ABSTRACT

Introduction.  Finasteride has been associated with reversible adverse sexual side effects in multiple randomized, controlled trials for the treatment of male pattern hair loss (MPHL). The Medicines and Healthcare Products Regulatory Agency of the United Kingdom and the Swedish Medical Products Agency have both updated their patient information leaflets to include a statement that “persistence of erectile dysfunction after discontinuation of treatment with Propecia has been reported in post-marketing use.”



Aim.  We sought to characterize the types and duration of persistent sexual side effects in otherwise healthy men who took finasteride for MPHL.



Methods.  We conducted standardized interviews with 71 otherwise healthy men aged 21–46 years who reported the new onset of sexual side effects associated with the temporal use of finasteride, in which the symptoms persisted for at least 3 months despite the discontinuation of finasteride.



Main Outcome Measures.  The types and duration of sexual dysfunction and the changes in perceived sexual frequency and sexual dysfunction score between pre- and post-finasteride use.



Results.  Subjects reported new-onset persistent sexual dysfunction associated with the use of finasteride: 94% developed low libido, 92% developed erectile dysfunction, 92% developed decreased arousal, and 69% developed problems with orgasm. The mean number of sexual episodes per month dropped and the total sexual dysfunction score increased for before and after finasteride use according to the Arizona Sexual Experience Scale (P < 0.0001 for both). The mean duration of finasteride use was 28 months and the mean duration of persistent sexual side effects was 40 months from the time of finasteride cessation to the interview date. Study limitations include a post hoc approach, selection bias, recall bias for before finasteride data, and no serum hormone levels.



Conclusion.  Physicians treating MPHL should discuss the potential risk of persistent sexual side effects associated with finasteride. Irwig MS and Kolukula S. Persistent sexual side effects of finasteride for male pattern hair loss. J Sex Med 2011;8:1747–1753.

Falloplastica per voluminosa lesione granulomatosa da autoiniezioni sottocutanee di paraffina

https://sites.google.com/site/urologiaandrologiadesiati/falloplastica-per-voluminosa-lesione-granulomatosa-da-autoiniezioni-sottocutanee-di-paraffina

SESSO: DISFUNZIONI LEGATE ALL'USO ALCOL, FUMO E ALL'OBESITA'

(ASCA) - Roma, 5 ago - Uno stile di vita non salutare e' strettamente connesso a problematiche dal punto di vista sessuale: e' quanto emerge da uno studio condotto su oltre 5 mila soggetti da un gruppo di ricercatori danesi dello Statens Serum Institut di Copenaghen e pubblicato sul Journal of Sexual Medicine.




I ricercatori hanno rilevato che mettere in pratica anche solo alcuni dei comportamenti tra l'essere in sovrappeso, fumare, bere alcol, consumare droghe pesanti e fare poca attivita' fisica porta a un aumento del rischio di non avere una vita sessuale regolare fino al 78% negli uomini e fino al 91% nelle donne. In particolare tra gli uomini il rischio di andare incontro a disfunzioni aumenta fino al 71% per i soggetti con obesita' addominale e di oltre l'800% in coloro che fanno uso di droghe pesanti. Le donne che fumano hashish corrono invece un rischio di sviluppare anorgasmia (difficolta' o impossibilita' a raggiungere l'orgasmo) 3 volte maggiore rispetto alle non utilizzatrici. noe/cam/bra